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L-Thyroxine sodium salt pentahydrate

CAS No. 6106-07-6

L-Thyroxine sodium salt pentahydrate( Sodium levothyroxine pentahydrate | Levothyroxine )

Catalog No. M24609 CAS No. 6106-07-6

L-Thyroxine sodium salt pentahydrate?is a synthetic hormone for the research of hypothyroidism.?DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
500MG 45 In Stock
1G 59 In Stock

Biological Information

  • Product Name
    L-Thyroxine sodium salt pentahydrate
  • Note
    Research use only, not for human use.
  • Brief Description
    L-Thyroxine sodium salt pentahydrate?is a synthetic hormone for the research of hypothyroidism.?DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
  • Description
    L-Thyroxine sodium salt pentahydrate?is a synthetic hormone for the research of hypothyroidism.?DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
  • In Vitro
    ——
  • In Vivo
    Deiodinases (DIOs), which catalyse the conversion of thyroxine (pro-hormone) to the active thyroid hormone, are associated with thyroid stimulating hormone (TSH) levels. DIO1 and DIO2 catalyze activation of thyroid hormone secretion in contrast to DIO3 playing role inactivation of the secretion. Activities of DIO1 and DIO2 play pivotal role in the negative feedback regulation of pituitary TSH secretion. L-Thyroxine (T4) and Triiodothyronine (T3) hormones are known to modulate the expression of ionic channels, pumps and regulatory contractile proteins. Moreover, thyroid hormones have been shown to influence calcium homeostasis and flux responsible for excitation and contractility, with L-Thyroxine and Triiodothyronine modulating its pharmacological control and secretion. In rats fed 12 weeks with the iodine-free diet, a significant decrease in the levels of both Triiodothyronine and L-Thyroxine is observed when compared to the control group fed with standard diet (p<0.001). In the group treated with low doses of L-Thyroxine, an increase in L-Thyroxine levels is observed (p=0.02) while Triiodothyronine levels remain virtually similar to the control group (p=0.19). Rats treated with high doses of L-Thyroxine display a significant increase in both Triiodothyronine and L-Thyroxine circulating concentrations compared to the non-treated hypothyroid group (p<0.001 and p=0.004, respectively) and a significant increase in L-Thyroxine levels when compared to the control values (p=0.03).
  • Synonyms
    Sodium levothyroxine pentahydrate | Levothyroxine
  • Pathway
    Endocrinology/Hormones
  • Target
    THR
  • Recptor
    Thyroid Hormone
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    6106-07-6
  • Formula Weight
    888.93
  • Molecular Formula
    C15H20I4NNaO9
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:28 mg/mL (31.50 mM)
  • SMILES
    C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)C[C@@H](C(=O)[O-])N.O.O.O.O.O.[Na+]
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Jan 11.
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