
L-Thyroxine sodium salt pentahydrate
CAS No. 6106-07-6
L-Thyroxine sodium salt pentahydrate( Sodium levothyroxine pentahydrate | Levothyroxine )
Catalog No. M24609 CAS No. 6106-07-6
L-Thyroxine sodium salt pentahydrate?is a synthetic hormone for the research of hypothyroidism.?DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
500MG | 45 | In Stock |
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1G | 59 | In Stock |
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Biological Information
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Product NameL-Thyroxine sodium salt pentahydrate
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NoteResearch use only, not for human use.
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Brief DescriptionL-Thyroxine sodium salt pentahydrate?is a synthetic hormone for the research of hypothyroidism.?DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
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DescriptionL-Thyroxine sodium salt pentahydrate?is a synthetic hormone for the research of hypothyroidism.?DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
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In Vitro——
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In VivoDeiodinases (DIOs), which catalyse the conversion of thyroxine (pro-hormone) to the active thyroid hormone, are associated with thyroid stimulating hormone (TSH) levels. DIO1 and DIO2 catalyze activation of thyroid hormone secretion in contrast to DIO3 playing role inactivation of the secretion. Activities of DIO1 and DIO2 play pivotal role in the negative feedback regulation of pituitary TSH secretion. L-Thyroxine (T4) and Triiodothyronine (T3) hormones are known to modulate the expression of ionic channels, pumps and regulatory contractile proteins. Moreover, thyroid hormones have been shown to influence calcium homeostasis and flux responsible for excitation and contractility, with L-Thyroxine and Triiodothyronine modulating its pharmacological control and secretion. In rats fed 12 weeks with the iodine-free diet, a significant decrease in the levels of both Triiodothyronine and L-Thyroxine is observed when compared to the control group fed with standard diet (p<0.001). In the group treated with low doses of L-Thyroxine, an increase in L-Thyroxine levels is observed (p=0.02) while Triiodothyronine levels remain virtually similar to the control group (p=0.19). Rats treated with high doses of L-Thyroxine display a significant increase in both Triiodothyronine and L-Thyroxine circulating concentrations compared to the non-treated hypothyroid group (p<0.001 and p=0.004, respectively) and a significant increase in L-Thyroxine levels when compared to the control values (p=0.03).
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SynonymsSodium levothyroxine pentahydrate | Levothyroxine
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PathwayEndocrinology/Hormones
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TargetTHR
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RecptorThyroid Hormone
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Research Area——
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Indication——
Chemical Information
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CAS Number6106-07-6
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Formula Weight888.93
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Molecular FormulaC15H20I4NNaO9
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Purity>98% (HPLC)
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SolubilityDMSO:28 mg/mL (31.50 mM)
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SMILESC1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)C[C@@H](C(=O)[O-])N.O.O.O.O.O.[Na+]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Jan 11.
molnova catalog



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